Delayed release of transmitter at the frog neuromuscular junction
نویسندگان
چکیده
منابع مشابه
Structural changes after transmitter release at the frog neuromuscular junction
The sequence of structural changes that occur during synaptic vesicle exocytosis was studied by quick-freezing muscles at different intervals after stimulating their nerves, in the presence of 4-aminopyridine to increase the number of transmitter quanta released by each stimulus. Vesicle openings began to appear at the active zones of the intramuscular nerves within 3-4 ms after a single stimul...
متن کاملPhenobarbital Increases Spontaneous Transmitter Release at the Frog Neuromuscular Junction
Phenobarbital (1-2 × 10(-4)M) markedly increases the frequency of miniature end-plate potentials at the neuromuscular synapse of the frog. This effect was seen in calcium free media containing EGTA. The drug probably acts presynaptically at an intracellular locus to increase the presynaptic free calcium concentration.
متن کاملTransmitter release at the neuromuscular junction.
NATIONAL REVIEW OF 105 OBIOLOGY, VOL. 75 Copyright 2006, Elsev All rights re 0.1016/S0074-7742(06)75006-1 0074-7742/06 II. P hysiological Properties of Transmitter Release III. E xperimental Advantages and Limitations of the Fly NMJ A. C a2þ Measurements B. D ye Loading C. A lternative Measures of Exocytosis IV. H ow Do Vesicles Fuse: Full Fusion or Kiss-and-Run? V. C ore Machinery of Exocytosi...
متن کاملEffects of changes in motor unit size on transmitter release at the frog neuromuscular junction.
The dependence of transmitter release and synaptic effectiveness on the size of a neuron's peripheral field was studied using neuromuscular junctions in sartorius muscles of adult frogs (Rana pipiens). The size of the peripheral field (motor unit size) was reduced by crushing the sartorius nerve and surgically removing half of the muscle fibers. Synapses thus formed were compared with those for...
متن کاملEvidence for Recycling of Synaptic Vesicle Membrane during Transmitter Release at the Frog Neuromuscular Junction
When the nerves of isolated frog sartorius muscles were stimulated at 10 Hz, synaptic vesicles in the motor nerve terminals became transiently depleted. This depletion apparently resulted from a redistribution rather than disappearance of synaptic vesicle membrane, since the total amount of membrane comprising these nerve terminals remained constant during stimulation. At 1 min of stimulation, ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 1973
ISSN: 0022-3751
DOI: 10.1113/jphysiol.1973.sp010084